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Non-nucleoside reverse transcriptase inhibitors Etravirine In the study of the interaction of a combination of primobolan depot cycle ritonavir (600/100 mg 2 times a day), and etravirine was found to decrease the concentration of etravirine by 37% and no significant changes in the concentration of darunavir. However, the combination  ritonavir can be simultaneously administered with 200 mg etravirine 2 times a day without changing the dose.

Efavirenz interaction study was conducted between the combination of darunavir / ritonavir (300 mg / 100 mg twice daily) and efavirenz (600 mg once day). In the presence of efavirenz was observed a decrease in plasma concentration of darunavir by 13%. On the other hand, efavirenz plasma concentration increased by 21% when it is applied simultaneously with a combination of darunavir / ritonavir. This interaction is not clinically significant and, therefore, / ritonavir and efavirenz can be used simultaneously without correction doses of drugs.

Nevirapine The results of studies of the interaction between the combination of darunavir / ritonavir (400 mg / 100 mg twice daily) and nevirapine (200 mg twice per day) showed that the plasma concentration of darunavir not dependent on the presence of nevirapine. However, while the use of a combination of darunavir / ritonavir plasma concentration of nevirapine increased by 27% (compared to control). This interaction is considered clinically insignificant, and therefore the combination of darunavir / ritonavir and nevirapine can be used simultaneously without changing their doses. Protease inhibitors Ritonavir In general, the effect of improving the pharmacokinetics of darunavir ritonavir manifested that darunavir plasma concentrations increased by approximately 14 times after a single dose darunavir (600 mg) and 100 mg ritonavir twice per day.

Therefore, the drug  should be used in combination with low dose ritonavir. The combination of lopinavir / ritonavir Results of studies of the interaction between the combination of darunavir / ritonavir (1200mg / 100mg twice a day) or 1200 mg of darunavir without ritonavir and lopinavir / ritonavir (400 mg / 100 mg twice per day or 533mg / 133,3mg twice daily) showed that decreased by 40% in the presence of lopinavir / ritonavir plasma concentration of darunavir. It is not recommended to use a combination of lopinavir / ritonavir at the same time with a combination of Prezista® / ritonavir. Saquinavir darunavir interaction study (400 mg twice daily), saquinavir (1000 mg twice daily) and ritonavir (100 mg twice daily) showed that darunavir plasma concentrations increased by 26% in the presence of saquinavir and ritonavir; On the other hand, the combination of darunavir / ritonavir does not affect the plasma concentration of saquinavir. Not recommended for use saquinavir simultaneously with , irrespective of whether a small additional dose of ritonavir. Atazanavir study the interaction between the combination of darunavir / ritonavir (400 mg / 100 mg twice daily) and atazanavir (300 mg once daily) showed no significant change concentrations of darunavir and atazanavir in plasma during their concomitant use. Atazanavir can be used simultaneously with the combination of darunavir / ritonavir. Indinavir A study of interaction between the combination of darunavir / ritonavir (400 mg / 100 mg twice daily) and indinavir (800 mg twice daily), darunavir plasma concentration increased by 24% in the presence of indinavir and ritonavir; in the presence of the combination of darunavir / ritonavir concentrations increased by 23% in indinavir plasma. When used in conjunction with a combination e ritonavir indinavir in patients who can not tolerate it may be reduced to 800 mg twice daily and 600 mg twice daily.

Other protease inhibitors
So far not studied the interaction between a combination of ritonavir and protease inhibitors in addition to lopinavir, saquinavir, atazanavir and indinavir, and hence no protease inhibitors listed here are not recommended for use in conjunction with the combination of darunavir / ritonavir.

Receptor antagonists In an application  ritonavir maraviroc should be administered at a dose of 150 mg 2 times a day. In a study of the interaction between a combination of darunavir / ritonavir (600 mg / 100 mg twice daily) and maraviroc (150 mg, 2 times a day) AUC maraviroc increased to 305%. The effects of maraviroc concentration of darunavir / ritonavir was observed. buy legal anabolic steroids online

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