Patients previously treated with protease inhibitors, primobolan depot dosage the recommended dose two times a day in combination with 100 mg ritonavir, two times a day; combination taken with food. The type of food does not influence the absorption of darunavir.
For patients previously treated with protease inhibitors, conducting genotypic testing is recommended.
Children: Patients 6 to 18 years, previously treated with antiretroviral therapy The recommended ritonavir for children from 6 to 18 years of age and weight at least 20 kg is dependent on body weight (see table below.) And should not exceed the recommended dose for adult patients (600/100 mg 2 times a day). Prezista should be taken with ritonavir two times per day with meals.The type of food does not influence the absorption of darunavir.
When you miss a dose and or ritonavir for 6 hours after the usual time of reception, it is necessary to take the prescribed dose or ritonavir, as soon as possible. In the case if more than 6 hours after ingestion normal time, it is recommended to follow the established drug regimen. These recommendations are based on a 15-hour half-life of darunavir in the presence of ritonavir and the established mode of drug administration every 12 hours. Patients with impaired hepatic function: In patients with mild or moderate violation of liver function dose adjustment is required. Information on the use of combination therapy primobolan depot dosageritonavir with severe hepatic dysfunction is absent; therefore give specific recommendations for dosage is not possible. Patients with impaired renal function. In patients with impaired renal function change doses in combination Prezista ® / ritonavir is required.
The most common adverse events moderate or severe (more than 2 degrees) are diarrhea, hypertriglyceridemia, rash, nausea, headache, and hypercholesterolemia. The most common side effects of severe (grade 3-4) are the increased activity of “liver” and pancreatic enzymes.
2.6% of patients discontinued therapy due to the occurrence of side effects.
The information on side effects in adult patients previously treated with antiretroviral therapy, when application 2 times per day is shown below.
Undesirable effects are grouped by frequency of occurrence and organs. The frequency is defined as: very often? 10%, often – 1-10%, rarely – 0.1-1%.
From the hematopoietic system and lymphatic system:
Infrequent: thrombocytopenia, neutropenia, anemia, increase in the number of eosinophils, leukopenia
Uncommon: Myocardial infarction, angina pectoris, prolongation of the interval QT, sinus bradycardia, tachycardia, palpitations, increased blood pressure, “tides” of blood
From the respiratory system:
Uncommon: dyspnoea, cough, epistaxis, rhinorrhea, sore primobolan depot dosage throat
From the digestive system:
Very common: diarrhea
Common: nausea, vomiting, abdominal pain, increased amylase, dyspepsia, abdominal distension, flatulence
Uncommon: pancreatitis, gastritis, gastroesophageal reflux, stomatitis, including aphthous, bloody vomiting, dry mouth, discomfort in the stomach, constipation, increased lipase activity, belching, breach of oral sensitivity, cheilitis, dryness of the lips, tongue coating
From the Hepatobiliary:
Common: increased activity of alanine aminotransferase and aspartate aminotransferase
Uncommon: hepatitis, including cytolytic, hepatic artery stenosis, hepatomegaly, increased transaminases, alkaline phosphatase, gamma-glutamyl transpeptidase, increased blood bilirubin